209860-87-7 Tafluprost ein neuartiges Prostanoid, das bei der Behandlung von Glaukom eingesetzt wird und das erste Prostanoid ist, das in einer Konservierungsfreien Formel freigesetzt wird.

Modell Nr.
209860-87-7
Lieferzeit
3days
Liefermethode
fedex/dhl/Sonderlinie
Transportpaket
25kg/Drum/1000g/Bag/10g/Bag
Spezifikation
100% raw material
Warenzeichen
Widely
Herkunft
China
Produktionskapazität
1000kg/Mon
Referenzpreis
$ 13.50 - 45.00
kontaktieren Sie uns

Produktbeschreibung

209860-87-7 Tafluprost a Novel Prostanoid Used in The Treatment of Glaucoma and Is The First Prostanoid to Be Released in a Preservative Free-Formula.
209860-87-7 Tafluprost a Novel Prostanoid Used in The Treatment of Glaucoma and Is The First Prostanoid to Be Released in a Preservative Free-Formula.
 
Description Glaucoma is second only to cataracts as a causative factor of blindness. By 2010, it is estimated that approximately 60 million people worldwide will be afflicted by glaucoma, so effective treatments should garner a large market. PG analogs have been widely used for lowering IOP by increasing uveoscleral outflow through agonism of the prostanoid FP receptor, and currently marketed versions include latanoprost, unoprostone isopropyl ester, bimatoprost, and travoprost. Compared to the carboxylic acid of latanaprost (K i =4.7 nM), the carboxylic acid of tafluprost displayed a 10-fold greater affinity for the prostanoid FP receptor (K i =0.4 nM). The synthesis of tafluprost begins with a Wittig condensation of the protected bicyclic lactone carbaldehyde with a dimethyl phosphonate ketone derivative.
Compared to the carboxylic acid of latanaprost (Ki 4.7 nM), the carboxylic acid of tafluprost displayed a 10-fold greater affinity for the prostanoid FP receptor (Ki 0.4 nM). The synthesis of tafluprost begins with a Wittig condensation of the protected bicyclic lactone carbaldehyde with a dimethyl phosphonate ketone derivative. The bottom appendage is then completed by the fluorination of the ketone with morpholino-sulfur trifluoride. Hydrolysis of the benzoate ester protecting group liberates the hydroxy group, and reduction of the lactone is accomplished with aluminum hydride to generate the lactol. Condensation of this intermediate with the phosphonium salt of the acid side chain generates the free acid, or active ingredient, which is subsequently esterified with 2-iodopropane in the presence of DBU. .
Originator Santen/Asahi Glass (Japan)
Uses Tafluprost is a novel prostanoid used in the treatment of glaucoma and is the first prostanoid to be released in a preservative free-formula.
Definition ChEBI: A prostaglandin Falpha that is prostaglandin F2alpha in which the carboxylic acid function has been converted to the corresponding isopropyl ester and the 3-hydroxy-1-octenyl side- hain is substituted by 3,3-difluoro-4-phenoxybut-1-enyl. Used for treatment of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
209860-87-7 Tafluprost a Novel Prostanoid Used in The Treatment of Glaucoma and Is The First Prostanoid to Be Released in a Preservative Free-Formula.
209860-87-7 Tafluprost a Novel Prostanoid Used in The Treatment of Glaucoma and Is The First Prostanoid to Be Released in a Preservative Free-Formula.
Hubei weideli Chemical Reagent Co., Ltd., located in Wuhan East Lake New Technology Development Zone, is a manufacturing supplier focusing on reagent products for scientific research, and its business scope includes the manufacturing of special chemical products; Disinfectant production; Sales of special chemical products; Disinfectant sales; Research and development of biological feed; Research and development of bio based materials technology; Research and development of biochemical products technology; Technical services, technical development, technical consultation, technical exchange, technology transfer and technology promotion; Sales of instruments and meters; Sales of daily glass products; Sales of technical glass products; Sales of electronic special materials; Technology import and export; Import and export of goods; Veterinary drug management; Production of disinfection products for the prevention and treatment of infectious diseases.

The company has gradually established extensive cooperation with scientific research institutions in Colleges and universities and powerful enterprises to lay a solid foundation for technological production; At the same time, we will recruit talents all over the country and keep them fresh and energetic; With more than ten years of experience and accumulation in the industry, the company further improves its market competitiveness and strengthens its support to customers.

With the help of modern ERP system, the company provides customers with accurate quotation and inventory information in time. It has a warehouse base and Laboratory of more than 1000 square meters in Jiangxia District, Wuhan. The system inventory products can be ordered on the same day, and the order number is given on the same day of delivery. The information can be queried online, followed up in real time, and customer service provides after-sales support services.

Hubei weideli Chemical Reagent Co., Ltd. is committed to scientific research.


I. Do you always have this products in stock?
Our company has more than 1000 kinds of products in stock. We usually have them 
in stock. We can show you the information, forms or pictures of our warehouse 
at any time. If the stock is insufficient, our company will replenish them as 
soon as possible according to the ERP system.

2. What certificates and documents do you offer?
According to the situation of products, we can provide COA, NMR, LC, MS, 
synthesis process, MQA, MSDS, etc

3. Why should I choose you?
Stock in stock and deliver in time
Reasonable price
Product technology and data support
Professional sales team
Perfect pre-sale and after-sale service

4. Can I get best price from you?
We don* t pursue expensive profits
We always try to give best offer
You can also enjoy fun of bargaining

5. How should I pay?
T/T bank transfer West union PayPal
 

 

Andere Medizinische Produkte

JCTK.CO.UK, 2023